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Treatment of H5N1 subtype avian influenza virus by ferroferric oxide biomagnetic beads

2019-04-07
The H5N1 subtype avian influenza virus (AIV) has long jeopardized the development of the poultry industry and brought huge losses to the national economy. In the early stage of the disease, rapid and accurate diagnosis has important implications for the development and control of the disease. Currently, the diagnosis of H5N1AIV depends on virus isolation, enzyme-linked immunosorbent assay (ELISA), and neuraminidase inhibition test (VN).
However, the sensitivity of these detection methods is low, and a small amount of virus cannot be detected. It is necessary to combine the process of virus proliferation, which increases the detection time, which is not conducive to the rapid response of the epidemic prevention personnel in the early stage of the disease. Therefore, we are looking for a way to enrich the detection of viruses in a sample, thereby eliminating the process of virus proliferation and shortening the detection time.
The immunomagnetic bead enrichment technique is an enrichment method established by magnetic beads as a solid phase surface combined with immunological methods.
In 2009, he established the H5N1 AIV micro-magnetic capture system, which used magnetic beads coated with H1N1 antibody to enrich the virus containing N1 subtype by immunological methods, and then combined with specific primers targeting H5 subtype. -PCR to detect H5N1AIV.
However, the cost of production of immunomagnetic beads and the relatively high antibody requirements, we attempted to prepare a new type of biomagnetic beads to enrich H5N1AIV. Magnetic beads refer to a combination of various organic polymer materials containing active functional groups and inorganic magnetic materials by appropriate methods to form microbeads having a certain magnetic and special surface structure. In addition to its general magnetic bead properties, it can also be imparted to various functional groups such as COOH, COH, NH2, OH, etc. through chemical reactions such as copolymerization and surface modification.
The biomagnetic beads are magnetic beads prepared by coating a biological reagent on the surface of the chemically modified superparamagnetic beads, that is, biomagnetic beads. Sialic acid is the most prevalent receptor for many pathogenic and non-pathogenic viruses, bacteria, and protozoa. The most famous of these is the flu virus. AIV specifically binds to the α2,3-sialic acid (SA) receptor located in the lower respiratory tract. Moreover, there are abundant α2,3-sialic acid at both ends of the oligosaccharide of fetuin. We hypothesized that in the presence of both fetuin and avian influenza, AIV will bind to fetuin by accepting sialic acid in fetuin as a receptor.
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